张红星，男，黑龙江哈尔滨，工学博士，教授，bwin必赢院长。

bwin必赢教授，食品科学与工程一级学科带头人，博士毕业于中国农业大学食品科学与营养工程学院食品科学专业，兼任北京食品学会副理事长、农产品有害微生物及农残安全检测与控制北京市重点实验室主任、中国环科会绿色包装专委会秘书长，入选北京长城学者、北京市中青年骨干教师、北京市优秀人才。

研究方向为食品生物技术和食品微生物，主要开展益生菌及其代谢产物功能研究、食品发酵技术研究及功能性发酵食品开发，在乳酸菌素抗菌和调节肠道健康机制研究、益生菌降胆固醇和降血脂机制研究、益生菌在抗肿瘤的作用研究方面取得了一定成果。

主持或参与国家自然科学基金、国家863科技计划子课题、国家科技支撑项目子课题等国家级、省部级和企业横向项目40余项。发表科研论文100余篇，其中SCI收录论文30余篇。获得授权国家发明专利30余项，获得省部级科研成果奖、教学成果奖4项。

一、联系方式： E-mail：hxzhang511@163.com

二、学习工作经历：

1993-1999 黑龙江省卫生防疫站

1999-2002 哈尔滨商业大学 食品科学硕士研究生

2002-2005 中国农业大学 食品科学博士研究生

2007-2009 中国农业大学 生物学博士后

2005-至今 北京农学院 教授

三、研究领域及具体方向：

食品生物技术、食品微生物发酵与功能产物、食品安全检测与控制

四、近年教材与科研论文

规划教材：

①“十四五”省部级规划教材：《现代食品微生物学》 副主编

②“十一五”国家级规划教材：《现代食品微生物学》 副主编

③北京市精品教材: 《现代食品微生物实验技术》 副主编

代表性科研论文：

1. Wenbo Liu, Shuai Zhang, Chang Chen, Junhua Jin, Hui Liu, Zheng Bian, Wenjing Qi, Yuanhong Xie,Hongxing Zhang*. Development of a visual detection method forSalmonellabased on loop-mediated isothermal amplification using pyrophosphatase. FEMS Microbiol Lett. 2023, 370:fnad040.

2. He Wang, Junhua Jin, Xiaona Pang, Zheng Bian, Jingxin Zhu, Yanling Hao,Hongxing Zhang*, Yuanhong Xie*. Plantaricin BM-1 decreases viability of SW480 human colorectal cancer cells by inducing caspase-dependent apoptosis. Front Microbiol. 2023, 13:1103600.

3. Yan Zhang, Yubing Hou, Shunliang Zhang, Nanqing Jing,Hongxing Zhang, Yuanhong Xie, Hui Liu, Jianguo Yan, Jianhua Ren, Junhua Jin.Bifidobacterium animalisA12, a Probiotic Strain That Promotes Glucose and Lipid Metabolism, Improved the Texture and Aroma of the Fermented Sausage. Foods. 2023, 12(2):336.

4. Nanqing Jing, Fudong Liu, Ran Wang, Yan Zhang, Jianjun Yang, Yubing Hou,Hongxing Zhang, Yuanhong Xie, Hui Liu, Shaoyang Ge and Junhua Jin. Both live and heat-killedBifidobacterium animalisJ-12 alleviated oral ulcers in LVG golden Syrian hamsters by gavage by directly intervening in the intestinal flora structure. Food Funct. 2023, 14(4):2045-2058.

5. Zheng Bian, Wenbo Liu, Junhua Jin, Yanling Hao, Linshu Jiang, Yuanhong Xie*,Hongxing Zhang*. Rcs phosphorelay affects the sensitivity ofEscherichia colito plantaricin BM-1 by regulating biofilm formation. Front Microbiol. 2022, 13:1071351.

6. Zheng Bian, Wenbo Liu, Junhua Jin, Yanling Hao, Linshu Jiang, Yuanhong Xie*,Hongxing Zhang*. Development of a recombinase polymerase amplification assay with lateral flow dipstick (RPA-LFD) for rapid detection ofShigellaspp. and enteroinvasiveEscherichia coli. PLoS One. 2022, 17(12):e0278869.

7. Yifei Liu, Yawen Wang, Xinyue Chen, Junhua Jin, Hui Liu, Yanling Hao,Hongxing Zhang*,Yuanhong Xie*. BasS/BasR Two-Component System Affects the Sensitivity ofEscherichia colito Plantaricin BM-1 by Regulating the Tricarboxylic Acid Cycle. Front Microbiol. 2022, 13:874789.

8. Jianjun Yang, Chenyang Dong, Fazheng Ren, Yuanhong Xie, Hui Liu,Hongxing Zhang*, Junhua Jin*.Lactobacillus paracaseiM11-4 isolated from fermented rice demonstrates good antioxidant propertiesin vitroandin vivo. J Sci Food Agric. 2022, 102(8):3107-3118.

9. Jianjun Yang, Yumeng Ma, Tong Li, Yuanxiang Pang,Hongxing Zhang, Yuanhong Xie, Hui Liu, Yanfang Sun, Jianhua Ren, Junhua Jin. Ameliorative Effects ofBifidobacterium animalissubsp.lactisJ-12 on Hyperglycemia in Pregnancy and Pregnancy Outcomes in a High-Fat-Diet/Streptozotocin-Induced Rat Model. Nutrients. 2022, 15(1):170.

10. Xinyue Chen, Yifei Liu, Junhua Jin, Hui Liu, Yanling Hao,Hongxing Zhang*, Yuanhong Xie*. YbfA Regulates the Sensitivity ofEscherichia coliK12 to Plantaricin BM-1 via the BasS/BasR Two-Component Regulatory System.Front Microbiol. 2021,12:659198.

11. Yuanxiang Pang, Jianjun Yang, Xinyue Chen, Yu Jia, Tong Li, Junhua Jin, Hui Liu, Linshu Jian, Yanling Hao,Hongxing Zhang*, Yuanhong Xie*. An Antifungal Chitosanase fromBacillus subtilisSH21.Molecules. 2021 Mar 25;26(7):1863.

12. Yiming Wang, Jiayi Li, Yuanhong Xie,Hongxing Zhang, Junhua Jin, Lixia Xiong, Hui Liu. Effects of a probiotic-fermented herbal blend on the growth performance, intestinal flora and immune function of chicks infected withSalmonella pullorum. Poult Sci. 2021 Jul;100(7):101196.

13. Junhua Jin, Linxia Jie, Hanwei Zhang, Yuanhong Xie, Hui Liu, Xiuzhi Gao,Hongxing Zhang*. Pediocin AcH Is Transcriptionally Regulated by a Two-Component System inLactobacillus plantarumsubsp.plantarum. J Food Prot. 2020;83(10):1693-1700.

14. Wang H, Xie YH, Zhang HW, Jin JH,Zhang HX*. Quantitative proteomic analysis reveals the influence of plantaricin BM-1 on metabolic pathways and peptidoglycan synthesis inEscherichia coliK12. PLoS One, 2020,15(4):e0231975.

15. Caicai Chen, Jiayi Li,Hongxing Zhang, Yuanhong Xie, Lixia Xiong, Hui Liu, Fang Wang. Effects of a probiotic on the growth performance, intestinal flora, and immune function of chicks infected withSalmonella pullorum. Poult Sci. 2020, 99(11):5316-5323.

16. Yang W, Xie Y, Jin J, Liu H,Zhang H*. Development and Application of an Active Plastic Multilayer Film by Coating a Plantaricin BM-1 for Chilled Meat Preservation. J Food Sci. 2019 Jul;84(7):1864-1870.

17. Xie Y, Zhang M, Gao X, Shao Y, Liu H, Jin J, Yang W,Zhang H*. Development and antimicrobial application of plantaricin BM-1 incorporating a PVDC film on fresh pork meat during cold storage. J Appl Microbiol. 2018 Oct;125(4):1108-1116.

18. Wu SQ,Zhang HX, Zhou HM, Jin JH, Xie YH*. Synergistic effect of plantaricin BM-1 combined with physicochemical treatments on the control of Listeria monocytogenes in cooked ham. J Food Prot, 2017 Jun; 80(6):976-981.

19. Zhong SQ, Liu H,Zhang HX, Han T, Jia H, Xie YH*. Effects of Kluyveromyces marxianus isolated from Tibetan Mushroomsn on the plasma lipids, egg cholesterol level, egg quality and intestinal health of laying hens. Rev Bras Cienc Avic. 2016, 18:261-7.

20. Jin JH, Song J, Ren FZ,Zhang HX, Xie YH, Ma J, Li X. Investigation of Growth Phase-Dependent Acid Tolerance inBifidobacteria longumBBMN68. Curr Microbiol. 2016 Nov;73(5):660-667.

21. Zhou HM, Xie YH, Liu H, Jin JH, Duan HX,Zhang HX*. Effects of two application methods of plantaricin BM-1 on control ofListeria monocytogenesand background spoilage bacteria in sliced vacuum-packaged cooked ham stored at 4 degrees. J Food Prot. 2015, 78(10):1835-1841.

22. Jin JH, Qin Q, Guo HY, Liu S, Ge S,Zhang H, Cui J, Ren FZ*. Effect of Pre-Stressing on the Acid-Stress Response inBifidobacteriumRevealed Using Proteomic and Physiological Approaches. PLoS ONE, 2015, 10(2):e0117702.

23. Xie YH,Zhang HX, Liu H*, Xiong LX, Gao XZ, Jia H, Lian ZX, Tong NS, Han T. Hypocholesterolemic effects of Kluyveromyces marxianus M3 isolated from Tibetan mushrooms on diet-induced hypercholesterolemia in rat. Braz J Microbiol. 2015, 46(2):389-395.

24. Hongxing Zhang, Yanling Hao, Dapeng Zhang, Yunbo Luo*. Characterization of the cryptic plasmid pTXW from Lactobacillus paracasei TXW. Plasmid, 2011, 65 (2011) : 1–7.

25. Hongxing Zhang, Yu-kui Rui. Nutritional composition of the speciality ‘‘frozen pear’’from the Northeastern of China. Journal of Consumer Protection and Food Safety, 2010, 5: 345–346.

26. Zhang Hongxing. Simultaneous Determination of Content of Ten Heavy Metals in Detergents from China by ICP-MS. Asian Journal of Chemistry, 2010, 22(6): 4777-4780.

27. Y.Hao, L.Zhao,H.Zhang. Identification of the bacterial biodiversity in koumiss by denaturing gradient gel electrophoresis and species-specific polymerase chain reaction. Journal of Dairy Science, 2010, 93: 1926-1933.

28. Zhang Hongxing, Zhu Benzhong, Yu Bianyun, Hao Yanling, Fu Daqi, Xu Wentao & Luo Yunbo*. Cloning and DNA-binding properties of ethylene response factor, LeERF1 and LeERF2, in tomato. Biotechnology Letters, 2005. 27: 423–428.

五、授权国家发明专利